The polyfunctionality index has been applied in numerous studies:
Download our recent poster related to the study by Sauce et al. Sci Rep 2016 (see below).
In vitro T cell analysis:
| Lissina et al. AIDS 2014 |
The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate.
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| Hill et al. JI 2014 |
Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations.
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| Lissina et al. JI 2016 |
Priming of Qualitatively Superior Human Effector CD8+ T Cells Using TLR8 Ligand Combined with FLT3 Ligand.
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Ex vivo T cell analysis:
| Larsen et al. PLoS One 2012 |
Evaluating cellular polyfunctionality with a novel polyfunctionality index.
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| Antoine et al. JID 2014 |
Postnatal acquisition of primary rhesus cytomegalovirus infection is associated with prolonged virus shedding and impaired CD4+ T lymphocyte function.
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| Goulenok et al. AIDS 2015 |
Increased carotid intima-media thickness is not associated with T-cell activation nor with cytomegalovirus in HIV-infected never-smoker patients.
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| Huygens et al. JID 2015 |
Functional Exhaustion Limits CD4+ and CD8+ T-Cell Responses to Congenital Cytomegalovirus Infection.
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| Boyd et al. PLoS One 2015 |
Pathogen-Specific T Cell Polyfunctionality Is a Correlate of T Cell Efficacy and Immune Protection
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| Lin et al. Nat Biotechnology 2015 |
COMPASS identifies T-cell subsets correlated with clinical outcomes.
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| Hassouneh et al. Mech Ageing Dev 2016 |
Effect of age and latent CMV infection on CD8+ CD56+ T cells (NKT-like) frequency and functionality.
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| Sauce et al. Sci Rep 2016 |
HIV-specific Th2 and Th17 responses predict HIV vaccine protection efficacy.
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| Samri et al. AIDS 2016 |
Polyfunctional HIV-specific T-cells in post-treatment controllers.
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| Bajwa et al. JID 2016 |
Functional diversity of CMV-specific T cells is maintained in older people and significantly associated with protein specificity and response size.
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| Pera et al. JLB 2016 |
CMV induces expansion of highly polyfunctional CD4+ T cell subset coexpressing CD57 and CD154.
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| Brinza et al. Sci Rep 2016 |
Immune signatures of protective spleen memory CD8 T cells.
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| Leroux-Roels et al. Clin Immunol 2016 |
Impact of adjuvants on CD4(+) T cell and B cell responses to a protein antigen vaccine: Results from a phase II, randomized, multicenter trial.
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| Bajwa et al. JID 2017 |
CMV-Specific T-cell Responses at Older Ages: Broad Responses With a Large Central Memory Component May Be Key to Long-term Survival.
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| Abdel-Hakeem et al. PLoS Path 2017 |
Selective expansion of high functional avidity memory CD8 T cell clonotypes during hepatitis C virus reinfection and clearance.
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| Burel et al. JCI Insight |
Polyfunctional and IFN-γ monofunctional human CD4+ T cell populations are molecularly distinct.
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Ex vivo DC analysis:
| Smolen et al. JI 2014 |
Single-cell analysis of innate cytokine responses to pattern recognition receptor stimulation in children across four continents.
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The Funky Cells ToolBox software from Funky Cells has also been used in contexts other than polyfunctionality:
Phenotypic analysis of NK cell ex vivo:
| Bayard et al. EJI 2016 |
Coordinated expansion of both memory T cells and NK cells in response to CMV in human.
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